THE MODERN BIO / JOURNAL
Fresh perspectives on health, longevity and the science shaping what’s next.
Explore more storiesIn a small exploratory analysis from a lung-disease trial, rentosertib shifted six protein-based aging clocks toward younger estimates. The signal is intriguing—but it cannot yet separate healthier disease biology from actual rejuvenation.
KEEP YOUR CURIOSITY GOING
A new FDA-authorized wearable can track glucose and ketones simultaneously. The immediate impact is diabetes safety—but the larger story may be the transition from occasional health measurements to continuous physiology.
GLP-1 microdosing is attracting attention as a possible longevity strategy, but no published randomized clinical evidence has shown that it extends lifespan, slows biological aging or prevents age-related disease in otherwise healthy adults.
A precisely formulated low-valine diet extended median lifespan by 23% in male mice and improved several health measures in both sexes. But valine is essential, the female mice did not live longer and no human longevity trial exists.
A biological-age test may report that you are younger—or older—than your birth certificate suggests. But different clocks measure different biology, can disagree in the same person and have not yet been proven to show that an intervention extends healthspan.
The first oral PCSK9 inhibitor lowered LDL cholesterol by approximately 56% to 59% in phase 3 trials. That is an important advance—but preventing heart attacks, improving longevity and lowering a laboratory value are not interchangeable claims.
An FDA advisory panel backed six popular peptides for possible pharmacy compounding—but that is not FDA approval or proof they work. Here is the evidence-minded interpretation of the vote, the human research and the unresolved safety questions.
Grip strength is a useful marker of function and aging. Learn what it measures, why it matters, its limits, and how to improve it safely.
Learn why VO2 max is a key longevity metric, how it’s measured, what affects it, and safe ways adults 35+ can improve it.
Learn how skeletal muscle supports metabolism, mobility, and resilience after 35—and how resistance training, protein, and recovery help preserve it.
Learn what Zone 2 cardio is, why it supports mitochondrial and metabolic health, and how to use it safely for long-term fitness.
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